The reference site for Ofloxacin

Ofloxacin is an antibiotic useful for the treatment of a number of bacterial infections. When taken by mouth or injection into a vein this includes pneumonia, cellulitis, urinary tract infections, prostatitis, plague and certain types of infectious diarrhea.

WHAT IS Ofloxacin?

Ofloxacin is in a group of antibiotics called fluoroquinolones, and works by fighting bacteria in the body.

This medicine is used to treat bacterial infections that cause bronchitis, pneumonia, chlamydia, gonorrhea, skin infections, urinary tract infections, and infections of the prostate.

Additionally, the ophthalmic solution is used to treat bacterial infections of the eye, such as conjunctivitis and corneal ulcers.

Ofloxacin is sold under the brand names Floxin® and Ocuflox® in both the U.S. and Canada.

 

Brand Name(s): Floxin; Ocuflox
CAS nº: 82419-36-1
(oh FLOX a sin)

Product Info

The sections below will provide you with more specific information and guidelines related to ofloxacin and its correct use. Please read them carefully.

FDA Information

Ofloxacin was initially approved for systemic use by the FDA in December 1990. This medicine is available in oral, parenteral, otic, and ophthalmic forms. The otic formulation was approved in December 17th 1997.

A prescription is required for this medicine.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Ofloxacin is in a group of antibiotics called fluoroquinolones, and works by fighting bacteria in the body.

This medicine is used to treat bacterial infections that cause bronchitis, pneumonia, chlamydia, gonorrhea, skin infections, urinary tract infections, and infections of the prostate.

Furthermore, the ophthalmic solution is used to treat bacterial infections of the eye, such as conjunctivitis and corneal ulcers.

Drug class and mechanism:

Ofloxacin is bactericidal via its effects on DNA gyrase, an enzyme responsible for counteracting the excessive supercoiling of DNA during replication or transcription. Although human cells do not contain DNA gyrase, they do contain a topoisomerase enzyme that functions in the same manner. This mammalian enzyme is not affected by bactericidal concentrations of quinolones. It is unclear how inhibition of DNA gyrase leads to bacterial cell death. Both rapid and slow growing organisms are inhibited by fluoroquinolones. In addition, fluoroquinolones exhibit a prolonged post-antibiotic effect (PAE). Organisms may not resume growth for 2-6 hours after exposure to ofloxacin, despite undetectable drug levels.

Other uses for this medicine

Ofloxacin (including other fluoroquinolones such as levofloxacin) may be used as an alternative treatment to ciprofloxacin for anthrax, despite that there is a lack of sufficient data on its efficacy. However, if first-line drugs were not available, these other fluoroquinolones may be effective.

It is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Ofloxacin is available in oral, parenteral, otic, and ophthalmic forms.

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.

Take ofloxacin with a full glass of water (8 ounces). Drink several extra glasses of fluid each day to prevent crystals from forming in the urine. Take this medicine on an empty stomach 1 hour before or 2 hours after meals.

Take this medicine at evenly spaced intervals, and for the entire length of time prescribed by your doctor.

Your symptoms may get better before the infection is completely treated. This medicine will not treat a viral infection such as the common cold or flu.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. It is important that you not miss any scheduled visits to your doctor.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using ofloxacin.

What special precautions should I follow?

BEFORE TAKING OFLOXACIN:

Tell your doctor if you have kidney disease, seizures or epilepsy, a history of head injury or a brain tumor. If you have any of these conditions, you may not be able to use ofloxacin, or you may need a dosage adjustment or special tests during treatment.

Moreover, inform your doctor if you are taking any of the following drugs: theophylline (Theo-Dur®, Theolair®, Slo-Phyllin®, Slo-Bid®, Elixophyllin®);probenecid (Benemid®); a blood thinner such as warfarin (Coumadin®);cimetidine (Tagamet®, Tagamet HB®); cyclosporine (Neoral®, Sandimmune®, Gengraf®); insulin or an oral diabetes medication such as glipizide (Glucotrol®),glyburide (Micronase®, Diabeta®, Glynase®), and others; or aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin®, Advil®), diclofenac (Voltaren®), indomethacin, naproxen (Aleve®, Naprosyn®),piroxicam (Feldene®), nabumetone (Relafen®), etodolac (Lodine®), and others. If you are using any of these drugs, you may not be able to use ofloxacin, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect ofloxacin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Additionally, there are certain medicines you should not take within the 2 hours before or after you take ofloxacin. This includes antacids that contain magnesium or aluminum (Tums® or Rolaids®), the ulcer medicine sucralfate (Carafate®), didanosine (Videx®), and vitamin or mineral supplements that contain iron or zinc. Taking these other medicines too close to your dose of ofloxacin can make the antibiotic much less effective.

Do not give this medicine to a child younger than 18 years old. Ofloxacin may interfere with bone development in a child.

This medication is in the FDA pregnancy category C. This means that it may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Furthermore, ofloxacin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Ofloxacin can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Ofloxacin can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.

What should I do if I forget a dose?

Take the missed dose as soon as you remember. If you are more than 2 hours late in taking your medicine, skip the missed dose and take the medicine at the next regularly scheduled time.

Never take extra medicine to make up for the missed dose.

What side effects can this medication cause?

Get emergency medical help if you have any of these signs of an allergic reaction:

hives
difficulty breathing
swelling of your face, lips, tongue, or throat

Stop using ofloxacin and call your doctor at once if you have any of these serious side effects:

seizure (convulsions)
confusion or hallucinations (seeing things that are not there)
a red, blistering, peeling skin rash
urinating less than usual or not at all
tremors or shaking
easy bruising or bleeding
unusual weakness
unusual thoughts or behavior
nausea, stomach pain, or loss of appetite
low fever
dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes)
sudden pain or swelling near your joints (especially in your arm or ankle)
numbness, burning, pain, or tingly feeling
diarrhea that is watery or bloody

Continue using ofloxacin and talk with your doctor if you have any of these less serious side effects:

feeling restless, nervous, or agitated
nausea, vomiting, or diarrhea
headache or drowsiness
vaginal itching or discharge
ringing in the ears
sleep problems (insomnia)

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Keep the medicine from freezing and do not refrigerate.

Also remember not to keep outdated medicine or medicine no longer needed, and be sure that any discarded medicine is out of the reach of children.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing, please call the local emergency services immediately on 911.

Symptoms of overdose may include:

drowsiness
nausea
hot or cold feeling
confusion
slurred speech

Product Images

PICTURES OF OFLOXACIN PRODUCTS

Below you will find images and specific information on the principal types of ofloxacin that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: OFLOXACIN
Strength(s): 200 MG
Imprint: RX 716
Manufacturer: RANBAXY

Name: FLOXIN®
Strength(s): 300 MG
Imprint: FLOXIN 300
Manufacturer: ORTHO PHARM.

Name: OFLOXACIN
Strength(s): 300 MG
Imprint: RX 715
Manufacturer: RANBAXY

Name: OFLOXACIN
Strength(s): 300 MG
Imprint: 93 | 7181
Manufacturer: TEVA USA

Name: OFLOXACIN
Strength(s): 400 MG
Imprint: RX 717
Manufacturer: RANBAXY

Name: OFLOXACIN
Strength(s): 400 MG
Imprint: 93 | 7182
Manufacturer: TEVA USA

Name: FLOXIN®
Strength(s): 400 MG
Imprint: FLOXIN 400
Manufacturer: ORTHO PHARM.

Name: OFLOXACIN
Strength(s): 0.03% / 5ML
Imprint: OFLOXACIN OPTHALMIC SOLUTION
Manufacturer: APOTEX INC.

Name: OFLOXACIN
Strength(s): 5ML
Imprint: OFLOXACIN
Manufacturer: ALEPPO PHARM.

Name: OCUFLOX®
Strength(s): 0.3% / 10 ML
Imprint: OFLOXACIN OPTHALMIC SOLUTION
Manufacturer: ALLERGAN

Name: FLOXIN®
Strength(s): 0.3% / 5 ML
Imprint: OFLOXACIN OTIC SOLUTION
Manufacturer: DAIICHI PHARM.

Name: FLOXIN®
Strength(s): 0.3% / 10 ML
Imprint: OFLOXACIN OTIC SOLUTION
Manufacturer: DAIICHI PHARM.

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